The process of Biofixation, the fixing of bacteria and fungi to mineral supports by chemi-osmoregulation, is at the centre of our biotechnical developments. It represents a considerable advance in the application of biotechnology and depends upon fixing selected strains of natural microorganisms to carefully chosen mineral supports. The unique combination of microbes and support gives the bacteria and fungi superior metabolic activity, toxin resistance and reproduction capacity that are substantially greater than found in free living and bio-augmented microorganisms.